Abstract

ORTIZ-ESTRADA, C.H.; DIAZ-DIAZ, C. Y.; CRUZ-OLIVARES, J.  and  PEREZ-ALONSO, C.. Coenzyme Q₁₀ microparticles formation with supercritical carbon dioxide. Rev. Mex. Ing. Quím [online]. 2015, vol.14, n.1, pp.49-59. ISSN 1665-2738.

Coenzyme Q₁₀ is a powerful antioxidant used on cardiovascular, neurodegenerative and cancer diseases. Its hydrophobic nature do limit its applications, because human body absorbs it with difficulty, that is why it was proposed to increase its bioavailability by diminishing the particle size using supercritical carbon dioxide. It was determined experimentally the phase behavior of the coenzyme in a supercritical system. The equilibrium data and a factorial 2^k experimental design were utilized to find how the shape and _tize of the microparticles are affected by temperature, coQ₁₀ concentration and nozzle diameter. Microparticles were characterized using infrared spectrometry and chromatography. For verify the fundamental chemical structure, the size and the shape of trie microparticles was used scanning electronic microscopy. It was found a significant decrease in particle size and a modification of physical structure. The antioxidant power of coQ₁₀ after micronization was meas ured, showing an increase of this property. Finally, in order to evaluate the bioavailability, the kinetic of solubility was determined in elhanol, having a substantial increase on solubilization speed of micronized coQ₁₀ compared with the commercial one.

Keywords : coenzyme Q₁₀; bioavailability; micronization; supercritical carbon dioxide.

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