Abstract

PENA-BALDERAS, Ana M.  and  LOPEZ-REVILLA, Rubén. Pharmacogenetics of adverse cutaneous reactions to lamotrigine. Rev. mex. neurocienc. [online]. 2019, vol.20, n.4, pp.200-206.  Epub Mar 22, 2022. ISSN 2604-6180.  https://doi.org/10.24875/rmn.19000051.

Cutaneous adverse drug reactions include maculopapular exanthema, Stevens-Johnson syndrome, and toxic epidermal necrolysis and are a global public health problem associated with the use of antiepileptic drugs (AEDs). Lamotrigine (LTG) stands out among AEDs because it does not cause sedation and does not affect cognition. Cutaneous adverse reactions (cADRs) to LTG occur in patients carrying certain allele variants of the human leukocyte antigen (HLA) system; although infrequent, they are alarming because they put the life at risk and force discontinuation of the treatment. The fear of neurologists to cADRs to LTG decreases its prescription despite its therapeutic advantages. Here, we review the allele variants of the HLA system that have been associated with cADRs to LTG in Mexican mestizos and other ethnic groups; identification of these variants would serve to select the patients that may be treated with LTG.

Keywords : Pharmacogenetics; Antiepileptic drugs; Lamotrigine; Cutaneous adverse drug reactions; Human leukocyte antigen system.

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