Abstract

ARANGO-MORALES, David  and  ARANGO-MORALES, Nidia. Ketone bodies as treatments for neurological illnesses. Rev. mex. neurocienc. [online]. 2023, vol.24, n.2, pp.52-57.  Epub June 12, 2023. ISSN 2604-6180.  https://doi.org/10.24875/rmn.22000062.

Ketone bodies such as β-hydroxybutyrate, acetoacetate, and acetone are produced mainly in the liver from fatty acids. In this way, they can be used by the body as an alternate source of energy. However, their properties go beyond an alternate source of energy. For many years, ketogenic therapies have been implemented for the treatment of certain neurological diseases, such as epilepsy. History shows us that its implementations were beneficial, minimizing the severity of seizures despite ignoring their mechanisms of action. At present, their applications and mechanisms are beginning to be understood.

Keywords : Ketone bodies; β-hydroxybutyrate; Ketogenic diet; Inflammasome; Neuroprotection.