Abstract

RIVERA, Gildardo et al. Medicinal chemistry in public health: our experience in the design of potential therapeutic molecules. Rev. mex. cienc. farm [online]. 2014, vol.45, n.1, pp.15-25. ISSN 1870-0195.

This paper briefly describes the progress that our research group has achieved in the design, synthesis and biological evaluation of new potential therapeutic molecules for public health problems such as obesity, cancer, tuberculosis, and American trypanosomiasis or Chagas disease. We briefly reviewed the relevance of each of these diseases, the drugs that have been used for treatment and those that are in development. Furthermore, we describe the rational design and synthesis strategies conducted by our research group, which have been focused on the development of new compounds with biological activity as potential anti-obesity, anti-cancer, anti-tuberculosis, and anti-trypanosomiasis agents.

Keywords : Medicinal chemistry; obesity; cancer; tuberculosis; trypanosomiasis.

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