Abstract

ESCARCEGA GONZALEZ, Carlos Enrique et al. The renal effects of a single and intravenous dose of titanium dioxide nanoparticles in adult male rats. Rev. mex. cienc. farm [online]. 2015, vol.46, n.1, pp.47-55. ISSN 1870-0195.

Most living organisms are exposed to nanomaterials. The renal effects of a single and intravenous dose (5 mg/kg) of titanium dioxide nanoparticles to male adult Wistar rats were obtained analyzing urine samples at 0-5 h, 5-24 h, 24-48 h and 48-72 h, giving as the earliest and significant (p < 0.05) effects: a) increase of the enzymatic activity of γ-glutamiltranspeptidase, and dipeptidylaminopeptidase at all times tested b) increase the concentration of urinary sodium at all times tested c) Increase the concentration of urinary glucose and the urine osmolarity at 5-24 h, 24-48 h, and 48-72 h. Thus, the titanium dioxide nanoparticles produced time-related effects in adult male rats. These renal effects could be used as another biomarker of exposure to nanoparticles.

Keywords : γ-glutamiltranspeptidase; dipeptidylaminopeptidase IV; glucose; osmolarity; sodium.