Abstract

LEON, Alejandra et al. Sesquiterpene Lactones, Acyl Phenyl Propanoids and Other Constituents from Schkuhria pinnata var. wislizeni: Antioxidant Evaluation. J. Mex. Chem. Soc [online]. 2009, vol.53, n.3, pp.193-200. ISSN 1870-249X.

Chemical investigation of aerial parts of Schkuhria pinnata var wislizeni (Asteraceae) allowed the characterization of the sesquiterpene lactones 1, 2 and 5, the flavonoids 3 and 4, and the acyl phenyl propanoids 10 and 11. Structure 2, named dischkuhriolin, was confirmed as a Diels Alder adduct of 1 as dienophile and a guaianolide as diene. Spectroscopic analysis of 5 and its diacetyl derivative allowed the structural correction of compounds previously reported from Schkuhria. 2, 10 and 11 are new natural compounds. Biological assays indicated that the mixture 10 + 11 showed antioxidant activity expressed as inhibition of AAPH-induced damage in rat pancreatic homogenate.

Keywords : Asteraceae; Schkuhria pinnata var. wislizeni; 11,13-dehydroeriolin; dischkuhriolin; 14-O-schkuhridin B; flavonoids; acyl phenyl propanes; antioxidant activity.