Abstract

ZAKY, M. et al. Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril. J. Mex. Chem. Soc [online]. 2014, vol.58, n.2, pp.142-151. ISSN 1870-249X.

Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.

Keywords : Lisinopril complexes; Infrared spectra; electronic spectra; thermal analysis; antimicrobial activity.