Abstract

BONILLA-LANDA, Israel et al. Design, Synthesis and Biological Evaluation of Novel Fungicides for the Management of Fusarium DieBack Disease. J. Mex. Chem. Soc [online]. 2018, vol.62, n.3, pp.86-98.  Epub July 02, 2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v62i3.531.

Fusarium Dieback, a new and lethal insect-vectored disease can host over 300 tree species including the avocado trees. This problem has recently attracted the attention of synthetic chemist not only to develop new triazol antifungal agents but also due to severe drug resistance to “classic” triazol antifungal agents. Here, a series of novel antifungal triazoles with a p-trifluoromethylphenyl moiety were synthesized and characterized by spectroscopic and spectrometric methods. Most of the target compounds synthesized showed from modest to good inhibitory activity and less phytotoxicity in comparison with the commercially available propiconazol; in particular, compounds 7 and 13 were active against both Fusarium solani and Fusarium euwallaceae. The results showed that compounds 7, 13, and 4 have great potential to be developed as new antifungal agents because of both good antifungal activity and low phytotoxicity. SAR showed that free alcohols and not O-protected compounds significantly influence the activity. Hence, α-methyl-α-1,2,4-triazole emerged as novel compound to develop new ketone-triazole-type antifungal agents for the management of Fusarium Dieback disease

Keywords : Fungicide; Synthesis; Triazol; Euwallacea; Fusarium.