Abstract

ORTEGA CHAVARRIA, María José; DIAZ GREENE, Enrique  and  RODRIGUEZ WEBER, Federico. Neuroleptic malignant syndrome. Acta méd. Grupo Ángeles [online]. 2019, vol.17, n.3, pp.282-286.  Epub Feb 11, 2022. ISSN 1870-7203.

Initially described in 1960 by Delay et al; it is a rare but potentially deadly. The presentation of hypothermia, alterations in consciousness levels, muscular rigidity and disautonomy are characteristic. It’s a secondary idiosyncratic response to the administration of neuroleptics, most frequently related with the administration of medications acting upon type 2 dopaminergic receptors. Treatment consists of discontinuing the drug, hemodynamic support and complication prevention. Mortality results from systemic complications and clinical manifestations. We present a case, a female patient with past medical history of major depressive disorder and generalized anxiety, she is admitted to the emergency room with clinical signs suggestive of malignant neuroleptic syndrome caused by intentional ingestion of multiple drugs; she is admitted to hospital for close monitorization.

Keywords : Neuroleptic malignant syndrome; hyperthermia; dopaminergic drugs; rhabdomyolysis.