Abstract

NAVARRETE HORTA, Teresa; GUERRERO CARRENO, Francisco Javier; VALDES AGUERREBERE, Paulina  and  VAZQUEZ ESTRADA, Leopoldo Alejandro. Estetrol: a new paradigm in gynecological therapy?. Acta méd. Grupo Ángeles [online]. 2022, vol.20, n.1, pp.50-57.  Epub Oct 10, 2022. ISSN 1870-7203.  https://doi.org/10.35366/103556.

Estetrol (E4) is a natural estrogen produced by the human fetus and passes into the maternal blood at relatively high levels during pregnancy. Over the past two decades, its pharmacodynamic and pharmacokinetic profiles, tolerability, and safety margin have been shown to be highly favorable. In this sense, E4 potentially represents a great advance in gynecological therapy such as contraception and the management of menopause. E4 also shows applicability in other therapeutic fields such as hormone-dependent cancers (breast and prostate), osteoporosis, neuroprotection, muscle pain, and wound healing. We present hereinafter the current evidence on this “new” hormonal therapy option whose inclusion in gynecological clinical practice seems imminent.

Keywords : Estetrol; E4; contraception; menopause; hormonal therapy.

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