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Revista mexicana de urología
On-line version ISSN 2007-4085Print version ISSN 0185-4542
Abstract
HALUN-TREVINO, Antonio Nassim; GONZALEZ-BONILLA, Eduardo Alberto; BARRERA-JUAREZ, Eduardo and GONZALEZ-OYERVIDES, Roberto. Clear cell adenocarcinoma in a diverticulum of the female urethra. A case report and literature review. Rev. mex. urol. [online]. 2021, vol.81, n.1, e08. Epub Mar 31, 2023. ISSN 2007-4085. https://doi.org/10.48193/revistamexicanadeurologa.v81i1.616.
Clinical case description:
A 64-year-old woman with an unremarkable past medical history was evaluated due to lower urinary tract symptoms and hematuria of 1-month progression. A magnetic resonance imaging scan revealed a lesion consistent with urethral tumor. During urethrocystoscopy, a tumor was found inside a urethral diverticulum. Transurethral resection was carried out, followed by the later performance of anterior pelvic exenteration. The histopathologic result was clear cell adenocarcinoma inside a proximal urethral diverticulum. The patient did not undergo adjuvant therapy, remaining in follow-up and surveillance, and is presently recurrence-free.
Relevance:
Urethral carcinoma is an uncommon tumor and its appearance in a diverticulum is rare. Those types of tumor are highly invasive and require aggressive treatment to offer the possibility of cure.
Clinical implications:
No standardized treatment is in place. Surgical treatment through radical urethrectomy or anterior pelvic exenteration, with or without adjuvant therapy, is the most widely accepted therapeutic option.
Conclusions:
Clear cell adenocarcinoma arising in a urethral diverticulum is uncommon and usually has a locally advanced presentation. There is no standardized treatment or follow-up for the disease.
Keywords : Clear cell adenocarcinoma; Anterior pelvic exenteration; Carcinoma of the urethra; Female urethra.