Objective:

To determine if there is an association between the metabolic syndrome (MetS) and the levels of prostate specific antigen (PSA) in men who attended prostate control at the urology service of the Belén de Trujillo Hospital.

Material and Methods:

An observational, analytical and cross-sectional study was carried out, in which 357 men between 50-70 years were included, who went to a prostate control at the Urology Service of the Belén de Trujillo Hospital during the period March - July of the year 2019, which met the selection criteria. According to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), patients were dichotomized by the presence or absence of MetS and the means of PSA levels in each group were calculated. Subsequently, a linear regression analysis was performed to assess the effect of age, BMI, prostate volume, blood plasma volume and lower urinary tract symptoms score on PSA levels.

Results:

In the group of men with MetS, the mean PSA levels were slightly lower than men without MetS (1.54 ± 2.39 vs. 1.85 ± 3.0); obtaining a difference of 0.31 ng/ml; however, this association was not statistically significant (p = 0.103). On the other hand, PSA levels were influenced by blood plasma volume (p = 0.007) and BMI (p = 0.017).

Conclusions:

The results obtained in this population affected that the presence of MetS had a non-significant association on PSA levels; however, these findings may be reflected by an antagonistic effect between each of the components of MetS.