Abstract

JIMENEZ, Juan C.  and  MIRANDA, Florencio. Serotonin-2C receptor agonist Ro 60-0175 decreases the expression of ethanol-induced locomotor sensitization. Acta de investigación psicol [online]. 2017, vol.7, n.3, pp.2823-2831. ISSN 2007-4719.  https://doi.org/10.1016/j.aipprr.2017.11.003.

The main goal of the present research was to evaluate the effects of 5-HT2C receptor agonist Ro 60-0175 on the expression of ethanol-induced locomotor sensitization. In order to determine if these effects result from a specific action of Ro 60-0175 on 5-HT2C receptors, we also examined the effects of the selective 5-HT2C receptor antagonist SB 242084 on Ro 60-0175's effects on the ethanol-induced locomotor sensitization. Different groups of rats were subjected to development of ethanol-induced locomotor sensitization. On the expression tests of the locomotor sensitization the effects of the Ro 60-0175 and SB 242084 on the ethanol-induced locomotor sensitization were evaluated. In addition, the pretreatment with SB 242084 on the effects of Ro 60-0175 on the ethanol-induced locomotor sensitization was also evaluated. The results showed that Ro 60-0175 produced a dose-dependent prevention of the expression of ethanol-induced locomotor sensitization. This effect was reversed by administration of SB 242084. These data suggest that 5-HT2C receptors play a regulatory role on ethanol-induced locomotor sensitization.

Keywords : Ethanol; 5-HT2C receptors; Addiction; Locomotor sensitization.

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