Abstract

CEDILLO ZAVALETA, Laura N.; JIMENEZ MEJIA, Juan C.; RUIZ-GARCIA, Rosa Isela  and  MIRANDA, Florencio. Administration of the mGluR2/3 APDC Decreases the Discriminative Signal of Amphetamine in Rats. Acta de investigación psicol [online]. 2021, vol.11, n.1, pp.16-26.  Epub Jan 14, 2022. ISSN 2007-4719.  https://doi.org/10.22201/fpsi.20074719e.2021.1.370.

Rewarding, motor and discriminative effects of amphetamine (AMPH) are mediated in large part by increased dopamine (DA) neurotransmission in the nucleus accumbens. However, there is evidence that the glutamate system may regulate forebrain DA function. Here, we examined the role of mGluR2/3 receptors on the discriminative stimulus properties of AMPH using conditioned taste aversion (CTA) as the drug discrimination procedure. Male Wistar rats were deprived of water and trained in the CTA procedure. They received the administration of AMPH (1.0 mg/kg) before a 10 min period of access to saccharin solution and followed by an injection of LiCl; on alternate days, rats received saline (1 ml/kg ip) before and after the access to saccharin solution. In generalization and combination tests, the AMPH was substituted by different doses of the mGluR2/3 receptor agonist (2R,4R)-APDC (0.1, 0.3 and 1.0 mg/kg ip), different doses of the mRGlu2/3 receptor antagonist LY341495 (1.0, 3.0 and 5.6 mg/kg ip), different doses of the mGluR2/3 receptor agonist APDC (0.1, 0.3 y 1.0 mg/kg ip) + AMPH (1.0 mg/kg ip) or different doses of the mGluR2/3 receptor antagonist LY341495 (1.0, 3.0 and 5.6 mg/kg ip) + APDC (1.0 mg/kg ip) + AMPH (1.0 mg/kg ip). The results showed that the agonist APDC significantly decreases the discriminative cue of the AMPH and this effect was reversed by the antagonist LY341495. These data suggest that mGluR2/3 receptors could play an important modulatory role in the discriminative cue of AMPH.

Keywords : Amphetamine; Drug Discrimination; mGluR2/3 Receptors; Conditioned Test Aversion; Dopamine.

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