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Cirugía y cirujanos
On-line version ISSN 2444-054XPrint version ISSN 0009-7411
Abstract
KOUKOURITAKI, Zambia et al. Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat. Cir. cir. [online]. 2021, vol.89, n.6, pp.776-784. Epub Feb 08, 2022. ISSN 2444-054X. https://doi.org/10.24875/ciru.20001023.
Aim:
The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats.
Methods:
Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsaturated fatty acids, which received a high-molecular polymer solution of artificial total enteral nutrition enriched with n-3 fatty acids and CONTROL which received a high-molecular polymer solution of artificial total enteral nutrition.
Results:
Reduction of the animals' body weight was observed in both groups, but there was no difference between the two groups. Regarding the level of cytokines interleukin (IL)-1b, IL-6, and tumor necrosis factor a (TNF-a) there was no statistically significant difference between the two groups. Ischemic lesions to the small bowel mucosa were observed in both groups. A statistically significant difference in the extent of intestinal lesions was observed between the two groups with the animals that received enteral nutrition enriched with n-3 fatty acid developing fewer lesions.
Conclusion:
Enteral nutrition enriched with n-3 polyunsaturated fatty acids reduces the mucosal lesions caused by mesenteric ischemia compared to standard enteral nutrition, by modifying the local, but not the systemic, immune, and inflammatory response.
Keywords : Cytokines; Immunonutrition; Intestinal ischemia; N-3 fatty acids; Small bowel; Ischemic enteritis.