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Cirugía y cirujanos
On-line version ISSN 2444-054XPrint version ISSN 0009-7411
Abstract
GENIS-MENDOZA, Alma D. et al. Longitudinal magnetic resonance evaluation of the schizophrenia model of neonatal lesion in the ventral hippocampus. Cir. cir. [online]. 2021, vol.89, n.6, pp.785-791. Epub Feb 08, 2022. ISSN 2444-054X. https://doi.org/10.24875/ciru.20001027.
Objective:
To evaluate the progression by means of nuclear magnetic resonance of the lesion in the schizophrenia model of lesion of the ventral hippocampal nucleus (LVNH).
Method:
Magnetic resonance imaging (MRI) were performed in male Wistar rats, from 8 days postnatal to 139 days, in animals with LNHV and without lesion (sham). The MRI were carried out on a Variant 7 T equipment. The data were analyzed with the Amira software, for a voxel-based morphometric analysis.
Results:
We observed the presence of hypersignals with a significant enhancement in the structures analyzed in the group with LVNH, and greater volume in the lateral ventricles, presenting a larger size of the lesion on day PD96 and significantly reducing on day PD139.
Conclusions:
We found a cell rearrangement during the progression of the lesion, which could be the effect of the activation of immune cells.
Keywords : Schizophrenia; Neonatal ventral hippocampal lesion; Magnetic resonance imaging.
