Services on Demand
Journal
Article
English (pdf)
Article in xml format
Article references
Automatic translation
Send this article by e-mailIndicators
Cited by SciELO 
Access statistics
Related links
Similars in
SciELO
Share
Permalink
Cirugía y cirujanos
On-line version ISSN 2444-054XPrint version ISSN 0009-7411
Abstract
YAZAR, Veli M. et al. Effect of dexpanthenol on wound healing in penile fracture model: An experimental study. Cir. cir. [online]. 2022, vol.90, suppl.2, pp.1-5. Epub Dec 20, 2023. ISSN 2444-054X. https://doi.org/10.24875/ciru.22000100.
Objectives:
In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue.
Materials and methods:
Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days.
Results:
No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively).
Conclusion:
Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.
Keywords : Dexpanthenol; Fibrosis; Penile fracture; Rat.
