Abstract

NOGUEZ-MENDEZ, Norma Angélica et al. De los acarreadores de oxígeno (HbCO) a los polimerosomas. Una mirada a las células artificiales. Mundo nano [online]. 2014, vol.7, n.12, pp.83-105.  Epub June 21, 2021. ISSN 2448-5691.

Artificial blood substitutes have several advantages over blood transfusion from donors, making that oxygen transport to tissues of the blood via erythrocytes, the main challenge of artificial blood development. Two strategies have been suggested for the development of oxygen carriers: the biomimetic approach HBOCs (Hemoglobin-based oxygen carriers) and abiotic approach. The first approach mimics nature in the form of transport oxygen to the tissues, while the second uses synthetic chemicals to achieve the same result. Thus, the source of artificial cells is related to the carriers of oxygen in the form of polihemoglobins and conjugated hemoglobins and although a completely artificial cell comparable to the red blood cell is still a dream, the development of lipid membranes, biodegradable polymer and nanoparticles, are astep towards that possibility.

Keywords : artificial cells; oxygen carriers; HBOC; polymersomes; polymeric membranes.