Abstract

LAZZARINI, Roberto et al. Las nanopartículas de oro de 20 nm inhiben la proliferación e invasión de células de carcinoma mamario humano MCF7, in vivo. Mundo nano [online]. 2015, vol.8, n.15, pp.96-107.  Epub June 05, 2021. ISSN 2448-5691.  https://doi.org/10.22201/ceiich.24485691e.2015.15.53886.

Breast cancer ranks as the most common malignancy among women worldwide, so it becomes important to search for new agents that act against the disease. Nanotechnology proposes the use of nanomaterials mainly made from gold (nanoAu). In vitro essays on tumor cells indicate that nanoAu induce uptake, possibly near the target cell nucleus and cause its fragmentation, resulting in cell death. Although the effects of nanoAu in vivo mouse model are promising, high costs and special care of animals (nude mice) is an obstacle to investigating this issue. The chorioallantoic membrane (CAM) of chick embryo is a robust economic model to mimic microenvironmental conditions of most tumors that affect humans. The aim of this study was to evaluate the effect on the proliferation and invasion of human breast carcinoma cells MCF7 in vivo chick embryo CAM conditions. Our results suggest that nanoAu can inhibit the proliferation of MCF7 cells and delay spread on the chick embryo CAM.

Keywords : gold nanoparticles; breast cancer; xenoimplant; cell proliferation.