Abstract

HERNANDEZ-CORTEZ, Enrique. Efecto de los anestésicos en el desarrollo cerebral de niños. Anest. Méx. [online]. 2016, vol.28, n.2, pp.32-37. ISSN 2448-8771.

Today the management of the majority of current anesthetics is challenging. The character of reversibility of these medications is being questioned. Especially if it's anesthetics to children under three years of age. Isoflurane administration increases the levels of intracellular calcium which is critical for cellular damage resulting in damage by apoptosis. NMDA and GABA receptors are indirectly involved in the condition of immature brains.

The immaturity of the central nervous system associated with the administration of anesthetic agents such as the inhaled, ketamine, midazolam, nitrous oxide and others, produces changes in the brain that affect the child's later life. In the neurotoxicity of anesthetics two things are important, dose and time of administration, repeat anesthetics produce brain changes. These changes have resulted in serious behavioral changes and memory in experimental animals. It is suspected that such a situation could occur in children who manifest learning in school ages.

Keywords : Apoptosis; anesthetics; cognitive impairment in children.