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Revista alergia México
On-line version ISSN 2448-9190
Abstract
GLOCER, Dina et al. Prophylaxis in hereditary angioedema with normal C1 inhibitor. Rev. alerg. Méx. [online]. 2021, vol.68, n.4, pp.304-306. Epub Apr 08, 2022. ISSN 2448-9190. https://doi.org/10.29262/ram.v68i4.850.
Introduction:
Hereditary angioedema is an infrequent genetic disorder; which mainly manifests with cutaneous and mucosal swelling. Minor trauma may trigger potentially life-threatening events. In type I and II hereditary angioedema, plasma-derived C1-inhibitor concentrate can be used as short-term prophylaxis. For hereditary angioedema, prophylaxis is not yet standardized, but normal C1 inhibitor could be beneficial.
Case report:
A 69-year-old woman, with a genetic diagnosis of hereditary angioedema with normal C1 inhibitor, who needed multiple dental extractions. The surgical procedure was performed under general anesthesia, using 1000 U of plasma-derived C1-inhibitor concentrate as prophylaxis an hour before. The patient was admitted in the ICU for postsurgical care and the outcome was good.
Conclusion:
We highlight the possibility of successfully using plasma-derived C1-inhibitor concentrate as prophylaxis in patients with hereditary angioedema with normal C1 inhibitor.
Keywords : Angioedema; C1 inhibitor; Factor XII; Odontology.