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Revista alergia México
On-line version ISSN 2448-9190
Abstract
LOPEZ-MARIN, Beatriz; OSORNO-GUTIERREZ, Adriana Patricia and ARREDONDO-VANEGAS, Natalia. Effect of pasteurization and freezing on the content of IgA1 and IgA2 subtypes in breast milk. Rev. alerg. Méx. [online]. 2023, vol.70, n.1, pp.15-21. Epub Aug 25, 2023. ISSN 2448-9190. https://doi.org/10.29262/ram.v70i1.1205.
Objective:
To determine the effect of pasteurization and freezing on the content of IgA1 and IgA2 in breast milk.
Methods:
Observational, retrospective study, carried out in women who had been breastfeeding their newborn for more than 30 days, and could donate 50 mL of milk. The concentration of IgA1 and IgA2 was determined by turbidimetry, before and after being subjected to pasteurization and freezing, every 15 days for 2 months. Freezing was at -20°C. A total IgA content of 1598.5 mg/dL was found.
Results:
10 breast milk donors were selected. The initial concentration of IgA1 and IA2 was 651 and 945.7 mg/dL, respectively; At the end of the freezing times, the content of both immunoglobulins decreased: IgA1 of 74% and IgA2 of 86%. After the treatments, the immunoglobulin content decreased dramatically, with a significant difference of p < 0.05.
Conclusion:
Pasteurization and freezing significantly affect the content of IgA1 and IgA in breast milk; therefore, breast-feeding remains the best way to offer full immunological protection to the infant.
Keywords : Milk human; Immunoglobulins; IgA1; IgA; Pasteurization; Freezing; Turbidimetry.
