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Gaceta mexicana de oncología
On-line version ISSN 2565-005XPrint version ISSN 1665-9201
Abstract
MACARI-JORGE, Andrés and ORTIZ-HIDALGO, Carlos. Hybrid peripheral nerve sheath tumor, with myxoid schwannoma, neuroblastoma-like schwannoma, and perineurioma components. Gac. mex. oncol. [online]. 2021, vol.20, suppl.1, pp.158-162. Epub Aug 22, 2022. ISSN 2565-005X. https://doi.org/10.24875/j.gamo.20000112.
A 43-year-old female presented with an oval eccentric solid lesion fixed to the submandibular gland. The tumor was composed of bland spindle cells embedded in a myxoid stroma with focal areas showing large cellular rosettes. Both areas were positive for S100 protein and glial fibrillary acidic protein. Some of the elongated spindle cells were also positive for epithelial membrane antigen, and glucose transporter 1, indicating perineurial cell differentiation. A diagnosis of hybrid tumor with myxoid schwannoma, neuroblastoma-like schwannoma and perineuroma components was rendered. The lesion was resected completely and has not recurred after eight months of resection.
Keywords : Peripheral nerve sheath tumors; Hybrid tumors; Schwannoma; Perineuroma; Immunohistochemistry.