Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Similars in SciELO
Share
Revista mexicana de oftalmología
On-line version ISSN 2604-1227Print version ISSN 0187-4519
Abstract
RIVERO-GUTIERREZ, Vanesa et al. Telomere length shortening associated with cataract in younger adults. Rev. mex. oftalmol [online]. 2021, vol.95, n.1, pp.1-7. Epub June 25, 2021. ISSN 2604-1227. https://doi.org/10.24875/rmo.m20000147.
Purpose:
A prospective observational study was performed that included 205 adults, 102 cases and 103 controls, classified into the age groups of ≤ 55 and ≥ 60 years old, to examine the prognostic value of telomere length in patients with or without cataract, and to assess the effects of telomerase ribonucleic acid (RNA) gene variants (TERC and TERT) on telomere length.
Methods:
Telomere length and telomerase polymorphisms were quantified in peripheral blood leukocytes by quantitative polymerase chain reaction. TaqMan® probes were used for telomerase polymorphisms (TERT 1327C>T and TERC 63G>A) genotyping.
Results:
Regardless of age, patients with cataract had shorter telomere lengths compared to healthy controls (p < 0.01). No association was detected between telomere shortening and TERC 63G>A in both cases and controls, and no correlation was observed between leukocyte telomere length and cardiovascular risk factors in patients with cataracts.
Conclusions:
Irrespective of age, telomeres in peripheral blood leukocytes of patients with cataract were shorter compared to subjects without cataract. Our findings suggest that the development of cataract is associated with peripheral blood cell aging.
Keywords : Cataract; Diabetes; Hypertension; Telomere length; Polymorphism; Smoking.