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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
MARTINEZ-JUAREZ, Iris E. et al. Electroencephalographic findings in asymptomatic relatives of patients with juvenile myoclonic epilepsy: relationship with the degree of kinship. Gac. Méd. Méx [online]. 2021, vol.157, n.4, pp.425-430. Epub 13-Dic-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000856.
Introduction:
A prevalence of 1 to 71 % of electroencephalogram (EEG) abnormalities has been reported in asymptomatic relatives of patients with juvenile myoclonic epilepsy (JME).
Objective:
To determine the frequency of EEG abnormalities in asymptomatic relatives of patients with JME according to the degree of kinship.
Methods:
Prospective, analytical study. First-, second- and third-degree relatives of patients with JME who agreed to participate and signed informed consent were included. The analysis was descriptive, bivariate.
Results:
209 asymptomatic relatives were included, out of which 115 (55 %) were females and 94 (45 %) were males, with a mean age of 35.9 ± 16.9 (range between 6 and 73 years). Forty-four (21.1 %) relatives had abnormal EEGs. First-degree relatives (12 %) had abnormalities more frequently in comparison with second- and third-degree relatives (p = 0.007).
Conclusions:
EEG abnormalities were observed in one third of asymptomatic relatives. It is important to highlight that there were more alterations among first-degree relatives. In the future, these findings might enable for the risk of clinically developing the disease to be estimated and for genetic counseling to be provided.
Palabras llave : Electroencephalogram; Juvenile myoclonic epilepsy; Asymptomatic relatives.