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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
LINO-SILVA, Leonardo S. et al. Recurrence rate and survival implications of surgical margins in patients with acral melanoma. Is a wide margin necessary?. Gac. Méd. Méx [online]. 2023, vol.159, n.1, pp.38-43. Epub 02-Mayo-2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.22000192.
Introduction:
Appropriate size of resection margins in acral melanoma is not clearly established.
Objective:
To investigate whether narrow-margin excision is appropriate for thick acral melanoma.
Methods:
Three-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm).
Results:
Out of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003).
Conclusion:
A resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma.
Palabras llave : Surgical margin; Acral melanoma; Survival.