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Revista mexicana de pediatría
versión impresa ISSN 0035-0052
Resumen
HERNANDEZ-ALCARAZ, Melissa y DUENAS-ARIAS, Jesús Ernesto. Philadelphia chromosome frequency in children with acute lymphoblastic leukemia. Rev. mex. pediatr. [online]. 2020, vol.87, n.5, pp.170-175. Epub 27-Jun-2022. ISSN 0035-0052. https://doi.org/10.35366/97170.
Introduction:
The BCR-ABL fusion oncogene, a product of the Philadelphia chromosome t(9; 22), is relatively rare in children with acute lymphoblastic leukemia (ALL). Its presence is indicative of a poor prognosis.
Objective:
To determine the frequency of Philadelphia chromosome in children with ALL at the Pediatric Hospital of Sinaloa, Mexico.
Material and methods:
Nine-year records (2008-2017) of RT-PCR experiments for BCR-ABL of patients diagnosed with ALL were reviewed.
Results:
Of 138 patients with ALL, three Philadelphia chromosome positive patients (2.17%) were identified. These three patients were male, aged two to eight years, and were classified as having high-risk ALL. Although they have presented relapses, currently all three are alive and remain in treatment.
Conclusion:
The frequency of 2.17% of the Philadelphia chromosome in children with ALL that we found in this study, is similar to the Figures described in other countries.
Palabras llave : Lymphoblastic leukemia; Philadelphia chromosome; pediatrics.