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Boletín médico del Hospital Infantil de México
versión impresa ISSN 1665-1146
Resumen
SAUCEDO-CAMPOS, Alberto et al. Acute myeloid leukemia associated with t(16:21)(p11;q22) in a pediatric patient. Bol. Med. Hosp. Infant. Mex. [online]. 2020, vol.77, n.6, pp.327-330. Epub 27-Nov-2020. ISSN 1665-1146. https://doi.org/10.24875/bmhim.20000025.
Background:
Rare subgroups of pediatric patients with acute myeloid leukemia (AML), such as t(16:21) (p11;q22), require international cooperation to establish a proper stratification system to assign clinical risk.
Case report:
Here, we report a 13-year-old female who was admitted for asthenia, fatigue, and intermittent fever. The hematological data showed thrombocytopenia and anemia, and the bone marrow test showed 82.5% blast cells, which were positive for CD13, CD33, CD38, and CD117. Blast cells showed negative myeloperoxidase staining and positive periodic acid–Schiff staining. A diagnosis of AML M6 was made. Cells were positive for the fusion transcript FUS-ERG t(16;21)(p11;q22). The patient achieved morphological remission. However, molecular remission was not achieved, and she died 11 months after diagnosis.
Conclusions:
It is essential to report this sporadic case of AML to provide clinicians with data for clinical decision-making, such as for risk-group stratification. To the best of our knowledge, this is the first association between this translocation and this morphological subtype.
Palabras llave : Pediatric acute myeloid leukemia; Acute myeloid leukemia M6; FUS-ERG fusion transcript.