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Revista mexicana de neurociencia
versión On-line ISSN 2604-6180versión impresa ISSN 1665-5044
Resumen
FLORES-SOBRECUEVA, Alejandro et al. A relationship between drug-resistant epilepsy and structural abnormalities in neuroimaging. Rev. mex. neurocienc. [online]. 2020, vol.21, n.1, pp.9-14. Epub 22-Mar-2022. ISSN 2604-6180. https://doi.org/10.24875/rmn.19000090.
Background and objectives:
The purpose of the study was to seek a relationship between drug-resistant epilepsy and structural alterations in neuroimaging to strengthen the link between the clinical and surgical management. A second objective was to determine an association between drug-resistant epilepsy and subject gender, the age of first seizure, and the type of seizure.
Materials and methods:
Over 632 medical records were scrutinized in search of those satisfying the inclusion criteria to end up with a sample of 108 subjects. Neuroimaging specialists reviewed each of the magnetic resonance imaging (MRI) studies looking for abnormalities to make the structural diagnosis and define it.
Results:
Of the 108 patients included in the study, 51 patients (Group A) were refractory to medical treatment and 57 patients (Group B) showed an improvement with medical treatment. We quantified the frequency of structural lesions confirmed by neuroimaging in both groups. The results showed a statistically significant difference of 84.31% of patients in Group A with a confirmed structural lesion in an MRI study versus 52.63% of patients in Group B (p = 0.004 [odds ratio = 4.85, 95% confidence interval: 2.01-11.66]).
Conclusion:
Our results support the association between structural lesions diagnosed with MRI and drug-resistant epilepsy. Thus, this finding gives a chance of an opportune and precise approach for the surgical treatment of these patients.
Palabras llave : Epilepsy; Drug-resistant epilepsy; Epilepsy surgery; Epilepsy neuroimaging.