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Journal of the Mexican Chemical Society
versión impresa ISSN 1870-249X
Resumen
MERUGU, Santha Kumari y BOLLIKOLLA, Hari Babu. Improved Knoevenagel Condensation Protocol for the Synthesis of Cyanoacrylates and their Anticancer Activity. J. Mex. Chem. Soc [online]. 2023, vol.67, n.1, pp.60-69. Epub 11-Mar-2024. ISSN 1870-249X. https://doi.org/10.29356/jmcs.v67i1.1835.
DIPEAc (diisopropylethylammonium acetate) has been used as a catalyst in the Knoevenagel condensation of aldehydes and ethyl cyanoacetate to produce cyanoacrylate with high yields. The reaction's key characteristics are a shorter reaction time, a large substrate scope, the viability of different functional groups, ease of work-up, and high yields, which provide environmental benefits. Furthermore, the anticancer activity of the synthesized series of cyanoacrylate derivatives was tested against A549, HT-29, and HepG2 cell lines.
Palabras llave : Ethyl cyanoacetate; diisopropylethylammonium acetate (DIPEAc); cyanoacrylate; Knoevenagel condensation; anticancer activity.