Servicios Personalizados
Revista
Articulo
Indicadores
Citado por SciELO
Accesos
Links relacionados
Similares en SciELO
Compartir
Salud Pública de México
versión impresa ISSN 0036-3634
Resumen
GARZA-OCANAS, Lourdes et al. Dexamethasone and diclofenac by LC-MS-MS as herbal product adulterants. Salud pública Méx [online]. 2013, vol.55, n.5, pp.498-504. ISSN 0036-3634.
Objective. To confirm the presence of dexamethasone and diclofenac as adulterants of an herbal product. Materials and methods. For identificaction and confirmation of drugs a method of instrumental analysis by liquid chromatography coupled with high pressure tandem mass spectrometry was used. Results. The presence of dexamethasone and diclofenac was confirmed in samples of 11 bottles of Reumofan Plus obtained from patients and/or physicians. The methodology used, allowed separation of stereoisomers dexamethasone and betamethasone, the relative abundances of product ions 237.2 and 279.2 m / z spectrally differentiate the compounds. Conclusions. The presence of dexamethasone and diclofenac was confirmed in samples of a product marketed as "100% natural" obtained from patients and / or physicians in a period from January to December, 2011.
Palabras llave : dexamethasone; diclofenac; chromatography liquid; tándem mass spectrometry; plant preparations.