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Salud Pública de México
versión impresa ISSN 0036-3634
Resumen
PIMENTEL, Juan; ZULUAGA, Germán; BORRERO, Elizabeth y ANDERSSON, Neil. Demographic and clinical factors associated with dengue mortality in Colombia: a case-control study. Salud pública Méx [online]. 2021, vol.63, n.1, pp.42-50. Epub 15-Ago-2022. ISSN 0036-3634. https://doi.org/10.21149/11193.
Objective:
To identify demographic and clinical factors associated with mortality due to severe dengue in five departments in Colombia.
Materials and methods:
Case-control study with patients admitted between 2009 and 2013. The cases were patients who died from dengue and the controls where patients with severe dengue who survived the disease. A multivariate analysis using the Mantel-Haenszel procedure identified risk factors associated with dengue mortality.
Results:
We analyzed 58 cases and 121 controls and identified four factors: in-hospital administration of dypirone (ORa=6.38 95%CI 2.41-16.86) and paracetamol (ORa=0.25 95%CI 0.10-0.61), comorbidities (ORa=3.52 95%CI 1.51-8.18), and a prior visit to the hospital (ORa=3.99 95%CI 1.63-9.77).
Conclusions:
Administration of dypirone in patients with severe dengue was associated with a higher risk of mortality. Considering that 20 countries have banned dipyrone because of its adverse effects, we advise against its use.
Palabras llave : severe dengue; dipyrone; mortality; risk factors; Colombia.