Objective:

To summarize the scientific evidence of adverse health effects of Covid-19 during pregnancy.

Materials and methods

We conducted a Cochrane rapid review. Meta-analysis of proportions and odds ratios (OR) were performed.

Results:

Frequent maternal events included invasive mechanic ventilation and admission to the intensive care unit (ICU); pregnancy complications were fetal distress and premature rupture of membranes; common comorbidities were obesity and asthma. Deliveries by cesarean section (C-section) due to Covid-19 were frequent (51%). The most frequent neonatal outcomes were low birthweight and prematurity; we identified cases of SARS-CoV-2 positive neonates (14%). Pregnant women with Covid-19 were more likely to deliver by C-section (pooled OR=6.7) and prematurely (pooled OR=2.9); neonates were more likely to be admitted to the neonatal ICU (pooled OR=5.9).

Conclusion:

The available evidence on Covid-19 during pregnancy is limited. Therefore, we cannot disregard adverse health effects on the mother-child pair, particularly those related to C-sections and premature deliveries.

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