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Salud Pública de México
versión impresa ISSN 0036-3634
Resumen
GONZALEZ-GONZALEZ, José Gerardo et al. Serological follow up of positive SARS-CoV-2 cases. Salud pública Méx [online]. 2022, vol.64, n.3, pp.243-248. Epub 30-Oct-2023. ISSN 0036-3634. https://doi.org/10.21149/13065.
Objective:
To describe the humoral response in a cohort with mild and asymptomatic SARS-CoV-2 infection previously identified in a community-based serological survey.
Materials and methods:
This study was an observational follow up of 193 subjects previously identified with positive anti-SARS-CoV-2 antibodies invited for a second test 112 days after the first sampling. All completed a standardized electronic questionnaire. IgM/IgG antibodies were determined using a qualitative IgM/IgG chemiluminescent immunoassay.
Results:
Among the 193 eligible subjects, a total of 174 (90%) attended the follow-up visit, and their serum samples were tested. Of the samples, 171 (98.3%) were still positive, and 3 (1.7%) were negative. Also, the cut-off index (COI) value of the immunoassay significantly increased from the first to the second test (P <0.001).
Conclusions:
Our findings support a sustained humoral response in individuals with mild and asymptomatic SARS-CoV-2 infection up to 112 days after a positive serologic baseline test, accompanied by increasing antibody titers.
Palabras llave : anti-SARS-CoV-2; SARS-CoV-2; Covid-19; antibodies; persistence; follow up.