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Boletín médico del Hospital Infantil de México
versión impresa ISSN 1665-1146
Resumen
RIVERO-BORRELL DE LA PARRA, Pedro; GONZALEZ-CRUZ, Miguel Á.; FERREIRO-MARIN, Alejandro y CASAUBON-GARCIN, Pablo R.. L-arginine-induced esophagitis, report of six cases. Bol. Med. Hosp. Infant. Mex. [online]. 2020, vol.77, n.1, pp.38-41. Epub 25-Feb-2021. ISSN 1665-1146. https://doi.org/10.24875/bmhim.19000109.
Background:
Drug-induced esophagitis is an uncommon diagnosis in the pediatric population. The following is a report of six adolescents with L-arginine-induced esophagitis.
Case reports:
All patients were under treatment with L-arginine for short stature. After using the prescribed medication for 1-3 months, all cases started with severe retrosternal pain, odynophagia, and dysphagia. The upper gastrointestinal endoscopies showed ulcers located in the mid esophageal mucosa.
Conclusions:
In the presence of acute severe odynophagia, dysphagia, and retrosternal pain, drug-induced esophagitis should be considered as a possible diagnosis. Treatment includes liquid diet, pain control, sucralfate, omeprazole, and interruption of L-arginine. In addition, the physician should explain preventive measures focused on patient and family education on the drug side effects and precise instructions on how to take medications, as well as a careful balance of risk and benefits of any medication. At present, there are no clinical trials that support the use of L-arginine in treatment of short stature.
Palabras llave : Esophagitis; Arginine; Endoscopy.