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Cirugía y cirujanos
versión On-line ISSN 2444-054Xversión impresa ISSN 0009-7411
Resumen
KURT, Begum et al. The effect of platelet-rich plasma on intra-abdominal adhesions in rabbit uterine horn model. Cir. cir. [online]. 2023, vol.91, n.6, pp.773-779. Epub 30-Ene-2024. ISSN 2444-054X. https://doi.org/10.24875/ciru.23000070.
Objective:
This study was carried out to investigate the effect of autologous platelet-rich plasma (PRP) on intra-abdominal adhesion at the cesarean section incision line in the uterus.
Material and methods:
As experimental animals 16 white New Zealand rabbits, 5-months-old, unmated, were used. Animals were divided into two groups the control group and PRP application group. In each group, a transverse incision was made to the uterus to mimic the cesarean section and sutured. Relaparotomy was performed 21 days after the first operation.
Results:
When the groups were evaluated in terms of inflammation, there was a significant difference between the two groups. When the groups were evaluated in terms of Mason’s Trichrome staining and fibrosis, There was a significant difference between groups. When the groups were evaluated in terms of vascular endothelial growth factor-1, there was also a significant difference between the groups. In an experimental rabbit uterine horn adhesion model, PRP is effective in preventing post-operative adhesion formation.
Conclusions:
This result may guide clinical studies using autologous PRP to prevent post-operative adhesion formation after gynecological operations.
Palabras llave : Gynecological surgery; Platelet-rich plasma; Post-operative complications- Repeat cesarean sections; Surgical adhesions.