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Gaceta mexicana de oncología
versión On-line ISSN 2565-005Xversión impresa ISSN 1665-9201
Resumen
LARA-REYES, Jesús A. et al. Prolactin increases cell migration of MCF-7 cells without inducing an epithelium-mesenchyme transition. Gac. mex. oncol. [online]. 2022, vol.21, n.2, pp.54-58. Epub 20-Jun-2022. ISSN 2565-005X. https://doi.org/10.24875/j.gamo.22000006.
Objective:
To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin.
Methods:
We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin.
Results:
The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin.
Conclusions:
Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.
Palabras llave : Prolactin; MCF-7 cells; Epithelial-mesenchymal transition; Cell migration assays; Cell movement; Breast neoplasms.
