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Neumología y cirugía de tórax
versión impresa ISSN 0028-3746
Resumen
FELIX-PONCE, Miroslava et al. Adverse effects during the treatment of multidrug-resistant tuberculosis with linezolid in Mexico. Neumol. cir. torax [online]. 2018, vol.77, n.4, pp.276-279. ISSN 0028-3746.
Background:
The treatment of multidrug-resistant tuberculosis (MDR-TB) has traditionally been unsuccessful. This is a multifactorial problem influenced by the poor effectiveness of some of the drugs in the scheme, loss to follow-up and adverse reactions to drugs. Linezolid is a drug that has been shown to be effective in patients with drug-resistant TB, but it has been little used in Mexico because of its high cost and high rate of adverse effects reported in the literature.
Material and methods:
Retrospective analysis of cases treated with linezolid due to drug-resistant tuberculosis or adverse reaction in a clinic specializing in tuberculosis.
Results:
In 11 patients who received linezolid due to drug-resistant tuberculosis or mycobacteriosis, we found only one case with an adverse reaction (anemia) that responded to treatment with erythropoietin.
Conclusions:
Adverse reactions with linezolid at doses of 600 mg/day in our limited experience were uncommon (9%).
Palabras llave : Tuberculosis; drug-resistant; linezolid; mycobacteriosis.