Resumen

SILVA-TIRADO, Mónica Paulina. DRESS syndrome. Med. interna Méx. [online]. 2019, vol.35, n.2, pp.325-331.  Epub 30-Sep-2020. ISSN 0186-4866.  https://doi.org/10.24245/mim.v35i2.2267.

Dress syndrome is a severe and idiosyncratic reaction of hypersensitivity to drugs, characterized by rash, fever, lymphadenopathy, hematological alterations and systemic compromise, the heterogeneity of the clinical presentation represents a diagnostic challenge for the clinician, a high clinical suspicion is required and the need to rule out a wide spectrum of differential diagnoses. Cutaneous reactions associated with drugs can be potentially fatal, early diagnosis can modify the patient’s prognosis. We describe the clinical case and treatment of a 15-year-old male patient with chronic renal failure who was hospitalized for generalized morbilliform lesions associated with fever, lymphadenopathy, splenomegaly and eosinophilia. Complementary studies ruled out infectious, autoimmune and neoplastic processes; the antecedent of recent intake of allopurinol together with clinical and laboratory data allowed to establish a definitive diagnosis of DRESS syndrome. Patient received topical and systemic corticosteroids, clinical manifestations reverted from the second week of hospitalization. We emphasize the importance of identifying risk factors associated with the development of this syndrome.

Palabras llave : DRESS syndrome; Drug Hypersensitivity Syndrome; Drug-related Side Effects and Adverse Reactions; Allopurinol.