OBJECTIVE:

To investigate the relationship between serum progesterone level on the day of oocyte retrieval and pregnancy outcomes in patients undergoing IVF.

MATERIALS AND METHODS:

Prospective cohort study of IVF-ICSI cycles, with long or antagonistic agonist protocol and with fresh embryo transfer on day 2-3. We proposed a serum progesterone level on p90 on day of oocyte retrieval. The main outcome analysed are biochemichal and clinical pregnancy and first trimester miscarriage.

RESULTS:

400 cycles of IVF-ICSI were studied, with long agonist protocol (n = 41) or antagonist (n = 359) and with fresh embryo transfer on day 2-3. Pregnancy rate was similar in both groups (41 vs 40.2%) and clinical pregnancy rate was lower (30.8 vs 33.5%), but it wasn’t statically significance. There was more miscarriage in elevation progesterone group (25.7 vs 43.8%), but it wasn´t statiscally significance.

CONCLUSION:

Progesterone elevation on oocyte retrieval are not associated with the IVF outcome, but there is a trend to lower clinical pregnancy and more miscarriages.