Resumen

SHAABAN, Mohamed; NASR, Hamdi; HASSAN, Amal Z.  y  ASKER, Mohsen S.. Bioactive secondary metabolities from endophytic Aspergillus fumigatus: Structural elucidation and bioactivity studies. Rev. latinoam. quím [online]. 2013, vol.41, n.1, pp.50-60. ISSN 0370-5943.

During the research for bioactive secondary metabolites from microorganisms, the endophytic fungi Aspergillus fumigatus sp. isolate R7 was found to produce a set of promising bioactive compounds (1-10) after its large scale fermentation, working up and purification using a series of chromatographic techniques. Structural elucidation of the yielded compounds using intensive studies of their NMR (¹H, ¹³C & 2D NMR) and mass (EI MS, ESI MS) spectrometry confirmed them as linoleic acid (1), R(-)-glycerol monolinoleate (2), bis-dethio-(bis-methyl-thio)-gliotoxin (3), fumiquinazoline-F (4), fumiquinazoline-D (5), (Z,Z)-N,N'-[1-[(4-Hydroxy-phenyl)-methylene]-2-[(4-methoxy-phenyl)-methylene]-1,2-ethanediyl]-bis-formamide (6), pyrazoline-3-one trimer (7), Tricho-9-ene-2α,3α,11α,16-tetraol (8), 2'-deoxy-thy-midine (9), and cerebroside A (10). In this article, taxonomical characterization, fermentation, structural characterization of the obtained metabolites were reported together with their antimicrobial and cytotoxic activities.

Palabras llave : Endophytic Fungi; Taxonomy; Secondary Metabolites; Structural Elucidation; Bioactivity.