Resumen

SANTOS MARTINEZ, Luis Efrén et al. Development of a canine model to produce a chronic, progressive right ventricular hypertension. Arch. Cardiol. Méx. [online]. 2001, vol.71, n.4, pp.266-277. ISSN 1665-1731.

Introduction: Several animal models of right ventricle hypertension (RVH) have been produced through pulmonary artery banding with linen, tygon or teflon. Nevertheless few devices attempting a progressive, step by step graduated chronic development of RVH have been reported. The present study describes the results in our animal model of chronic RVH. Material and methods: We designed a software programmed to obtain hemodynamic data and installed a small occlusive hydraulic device (OHD) at the pulmonary artery trunk producing a raise in the right ventricular systolic pressure (RVSP); this pressure can be modified externally through the OHD. We studied 12 healthy mongrel dogs (18 to 28 kg of weight) in the course of 6 months. Hemodynamic measurements were performed at different RVSP at two months intervals; (Baseline, 40 mmHg and 60 mmHg). Results: The software was useful to analyze several hemodynamic variables at each RVSP. At 60 mmHg, the end diastolic pressure of the right ventricle (RVEDP) increased from 4.2 ± 0.4 mmHg to 13.2 ± 1.1 mmHg, p < 0.000, accompanied with a fall in cardiac output adjusted to the dogs weight from 0.16 ± 0.03 L/min/kg to 0.09 ± 0.01 L/min/kg, p > 0.000. Also an increase of the end diastolic pressure of the left ventricle (LVEDP) from 7.4 ± 0.8 mmHg to 16.3 ± 2.8 mmHg, p < 0.000, was observed. RVSP was maintained in chronic condition and the intra-class correlation coefficient was 0.83, P < 0.005. Conclusions: Right ventricular chronic hypertension is created. The device is useful and reliable to maintain chronic increments of RVSP. The software permits a versatile analysis.

Palabras llave : Pulmonary hypertension; Right ventricular function; Right ventricle.