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Revista mexicana de neurociencia
versión On-line ISSN 2604-6180versión impresa ISSN 1665-5044
Resumen
GALNARES-OLALDE, Javier A. et al. Split hand phenomenon: An early marker for amyotrophic lateral sclerosis. Rev. mex. neurocienc. [online]. 2021, vol.22, n.4, pp.141-145. Epub 30-Jul-2021. ISSN 2604-6180. https://doi.org/10.24875/rmn.20000135.
Background:
Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration of upper and lower motor neurons. Time from symptom onset to confirmed diagnosis has been reported from 8 to 15 months in ALS.
Objectives:
To describe the frequency of the split hand phenomenon and propose it as an early biomarker for ALS diagnosis.
Methods:
A retrospective, analytical, descriptive, and single-center observational study was performed. The split hand ratio was determined by dividing distal abductor pollicis brevis/abductor digit minimi compound muscle action potentials; a result < 0.6 was considered present.
Results:
Fifty-four patients with ALS diagnosis were included in the study. The split hand ratio was identified in 61.5% of patients with definite ALS, in 68.7% with probable ALS, 80% with possible ALS, and in 50% with suspected ALS. The split hand phenomenon was identified in 60% of patients within 12 months of symptom onset.
Conclusion:
We provide evidence for an additional neurophysiological tool that helps early diagnosis of ALS.
Palabras llave : Amyotrophic lateral sclerosis; Motor neuron disease; Split hand phenomenon; El Escorial criteria.