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Revista mexicana de neurociencia

versión On-line ISSN 2604-6180versión impresa ISSN 1665-5044

Resumen

AGUILAR-FABRE, Liane et al. Electro-clinical relationship and source analysis of absence seizures in childhood. Rev. mex. neurocienc. [online]. 2022, vol.23, n.3, pp.86-91.  Epub 06-Jun-2022. ISSN 2604-6180.  https://doi.org/10.24875/rmn.21000049.

Purpose:

This study was to deepen into the electro-clinical relationship and source analysis of absence seizures in childhood.

Methods:

Thirty-three subjects were studied with clinical and electrophysiological diagnosis of absence seizures without antiepileptic medication, video-electroencephalogram was applied. We obtained clinical behavior and electrophysiological variables during seizures and General Linear Model was applied, with p < 0.05. Source analysis was carried out with VARETA method.

Results:

174 seizures were evaluated. 75.75% showed interictal epileptiform discharges (IED) and 12.12% showed posterior delta activity. There was an unequal behavior in relation with total electro-clinical seizures and presence or no of IED (p = 0.02), namely between subjects without IED in EEG and multifocal EEG (p = 0.008). Quantity of seizures recorded during HPV had a different behavior between subjects without IED in EEG and multifocal EEG (p = 0.03) and between focal and multifocal EEG (p = 0.04). Source analysis (VARETA) evidence the onset frontal of seizures in 57.47%, mesial and dorsolateral regions in 43% and 57%, respectively.

Conclusion:

These data suggest that absence seizures are not “generalized” if we considered global cortical activation but rather involve localized discharges from specific cortical regions, mainly frontal lobe.

Palabras llave : Absence seizures; VARETA; Source analysis.

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