Objective.

To characterize the adverse drug reactions of low frequency of appearance, received in the Provincial Coordinating Unit of Pharmacovigilance from 2014 to 2018.

Method:

Observational, descriptive, cross-sectional study of a series of cases in Pharmacovigilance, based on the spontaneous notification of suspected adverse reactions from 2014 to 2018, in Matanzas. The necessary information was obtained from the pharmacovigilance provincial database. Low-frequency adverse reactions are described in terms of sex, age, type of adverse effect, intensity and imputability, among other variables.

Results:

There were evaluated a total of 3407 adverse reactions due to low frequency medications. Those classified as occasional prevailed with 1,741 notifications (51.1%). Female sex and adults were the most reported. Analgesics followed by antimicrobials, and the drugs with the greatest involvement were dipyrone (7.1%) and ibuprofen (5.8%). Adverse reactions to moderate low frequency drugs (93.3%) and probable (72.2%) prevailed according to imputability.

Conclusions:

adverse reactions to low-frequency medications were reported in Matanzas, in the period 2014-2018, mostly occasional and probable in skin and appendages, produced by analgesics and antimicrobials in females and adults, of moderate intensity.

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