Servicios Personalizados
Revista
Articulo
Español (pdf)
Artículo en XML
Referencias del artículo
Traducción automática
Enviar artículo por emailIndicadores
Citado por SciELO 
Accesos
Links relacionados
Similares en
SciELO
Compartir
Permalink
Medicina crítica (Colegio Mexicano de Medicina Crítica)
versión impresa ISSN 2448-8909
Resumen
LOPEZ MORAN, Héctor Antonio et al. Vitamin D status in sepsis in the Adult Intensive Care Unit. Med. crít. (Col. Mex. Med. Crít.) [online]. 2021, vol.35, n.2, pp.65-78. Epub 25-Abr-2022. ISSN 2448-8909. https://doi.org/10.35366/99526.
Introduction:
Nowadays, Vitamin C research in sepsis has been of great importance. However, and especially in the critical care setting, there’s limited but significant evidence about the high prevalence of vitamin D deficiency in sepsis and septic shock patients; correlating with the severity and the organ dysfunction risk.
Material and methods:
Retrospective study, monocentric, observational and descriptive, sample taken by convenience. 492 patients were analyzed, which 105 had sepsis diagnosis, and 30 of these patients had vitamin D quantification. The median age was 56 years, predominantly male (70%), the main medical history were oncologic illness, immunosuppression. At the time of intensive care unit admission 73.3% were in shock state, 70% on mechanical ventilation, with a mean mortality score of 16 points (APACHE II score, 25% mortality risk), and 8 points in the SOFA score (15-20% mortality risk. According with the vitamin D levels, 2 groups were found: Insufficiency (less than 10 ng/mL) and deficiency (more than 10 ng/mL).
Results:
There was no significant age difference (p = 0.724), length of stay difference (p = 0.755), SOFA (p = 0.241). There is statistically significance on the APACHE II scores, with a mean score of 19.5 points in the less than 10 ng/mL group (mortality risk 25%), and 14.5 points in the greater than 10 ng/mL group (mortality risk 15%). Mortality estimation was 42.9% in the less than 10 ng/mL group, and 12.5% in the greater than 10 ng/mL group, however, this was not statistically significant data.
Conclusions:
There is no statistically significant correlation between vitamin D levels and hospital length of stay. Mortality was higher in patients with vitamin D levels lesser than 10 ng/mL (42.9%), and 12.5% mortality in those with levels greater than 10 ng/mL. However the study sample is small, it will be necessary to increase the number of patients in order to obtain more statistically significant data.
Palabras llave : Sepsis; vitamin D; mortality.
