Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Similares en SciELO
Compartir
Revista médica del Hospital General de México
versión On-line ISSN 2524-177Xversión impresa ISSN 0185-1063
Resumen
CADENA-SUAREZ, Ana R.. MiRNAs involved in the signaling pathways associated to the pathogenesis of idiopathic pulmonary fibrosis. Rev. med. Hosp. Gen. Méx. [online]. 2022, vol.85, n.1, pp.34-43. Epub 02-Mayo-2022. ISSN 2524-177X. https://doi.org/10.24875/hgmx.21000049.
Idiopathic Pulmonary Fibrosis (IPF) is a progressive and multifactorial interstitial lung disease whose pathophysiology remains unclear. The process initiates by repeated epithelial lung injuries followed by basal membrane destruction occasioning the activation of the epithelial mesenchymal transition (EMT) and myofibroblasts which carry out an excessive synthesis of extracellular matrix (ECM) proteins. Several studies have associated microRNAs (miRNAs) to the biogenesis and development of IPF because miRNAs participate in the processes of apoptosis, proliferation, differentiation and interaction between cells thanks to their role as activators or inhibitors of different receptors in the signaling pathways of TGF-β, Wnt/β-catenin and PI3K-Akt-FOXO3a-mTOR, which are the main and most studied pathways involved in lung fibrosis. In this context, the knowledge on the altered miRNAs expression and even more their role in the different signaling pathways in IPF will shed light on new therapeutic targets for this lung disease.
Palabras llave : miRNAs; Idiopathic pulmonary fibrosis; Epithelial mesenchymal transition; Myofibroblasts.