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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
TORRES-ALARCON, Carmen G. et al. Blood system ABO antigens as risk factor for severity of SARS-CoV-2 infection. Gac. Méd. Méx [online]. 2021, vol.157, n.2, pp.181-187. Epub 23-Jun-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000498.
Introduction:
Whether there is an influence of the ABO blood system on susceptibility to the disease and its severity is unknown.
Objective:
To analyze if there is an association between the ABO blood system phenotypes and susceptibility to SARS-CoV-2 infection and its severity.
Material and methods:
The frequency of ABO antigens was compared in 73 confirmed cases of SARS-CoV-2 infection and 52 clinically healthy donors. The severity of the infection was evaluated by comparing the frequency of antigens by severity of the disease and mortality.
Results:
The risk of SARS-CoV-2 infection is increased in subjects with antigen A vs non-A subjects (OR=1.45; 95 %: 1.061-1.921). Blood phenotype O decreases the risk of SARS-CoV-2 infection (OR= 0.686; 95 % CI: 0.522-0.903). No differences were found regarding disease severity. The mortality risk is increased in subjects antigen A vs non-A (OR= 3.34; 95% IC: 1.417-8.159).
Conclusion:
Blood group A is a risk factor for SARS-CoV-2 infection, but not for disease severity, although in critically ill patients it is a risk factor for mortality.
Palabras llave : ABO blood group; SARS-CoV-2 infection; COVID-19.