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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
POPOCA-RODRIGUEZ, Ignacio y CARDENAS, Graciela. Cognitive impairment in patients with central nervous system tuberculosis. Gac. Méd. Méx [online]. 2021, vol.157, n.4, pp.385-390. Epub 13-Dic-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000742.
Introduction:
Tuberculosis in Mexico remains an important cause of morbidity and mortality; in the last four years, 110,681 cases of pulmonary tuberculosis and 1,571 cases of tuberculous meningitis were reported.
Objective:
To determine the neurocognitive sequelae, clinical presentation and neuroimaging alterations in patients with central nervous system tuberculosis.
Methods:
A retrospective, analytical, cross-sectional study was carried out from 2010 to 2019. Patients with central nervous system tuberculosis, with and without HIV/AIDS coinfection, were included.
Results:
During the study period, 104 cases with a definitive or probable central nervous system tuberculosis diagnosis were included; according to the Marais criteria, 38 % had HIV/AIDS coinfection, and 55 %, various comorbidities (p = 0.0001); 49 % had cognitive alterations, and 14 % died.
Conclusions:
Although HIV/AIDS infection can contribute to cognitive decline in patients with tuberculous meningitis, no differences were observed between patients with and without HIV/AIDS. Cognitive sequelae showed improvement during follow-up with adequate management and therapeutic control of the patients.
Palabras llave : Cognitive impairment; Cognitive sequelae; Tuberculous meningitis; Central nervous system; HIV/AIDS.