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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
LOPEZ-RODRIGUEZ, Guadalupe; GALVAN, Marcos y GALVAN VALENCIA, Oscar. Comorbidities associated with maternal mortality from COVID-19 in Mexico. Gac. Méd. Méx [online]. 2021, vol.157, n.6, pp.618-622. Epub 13-Dic-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.21000221.
Introduction:
In Mexico, there is a syndemic in pregnant women, where the epidemic of obesity and chronic diseases coexists with that of coronavirus disease 2019 (COVID-19), which has been associated with a higher risk of maternal mortality.
Objective:
To evaluate the association of comorbidities during pregnancy with maternal mortality from COVID-19 in Mexico.
Material and methods:
SISVER COVID-19 databases and epidemiological surveillance reports on maternal mortality were used. Multivariate logistic regression models were used to evaluate the association of comorbidities with maternal deaths from COVID-19.
Results:
A total of 29,416 pregnant women were evaluated, out of which 39 % were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the risk of maternal mortality was 3.24 times higher (p < 0.01) for positive in comparison with negative women. COVID-19 is the leading cause of maternal death since July 2020 and explains more than 50 % of total deaths in 2021. Chronic kidney disease (odds ratio [OR]: 4.11; p < 0.01) and diabetes (OR: 2.53; p < 0.01) were the two main comorbidities that were positively associated with maternal death from COVID-19.
Conclusion:
Comorbidities during pregnancy that are possibly associated with an increase in the inflammatory response and an alteration of the immune response increase the risk of maternal death from COVID-19 in Mexican pregnant women.
Palabras llave : Comorbidity; COVID-19; Maternal mortality; SARS-CoV-2.